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Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry (By similarity). Host restriction factors such as TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. Host PIN1 apparently facilitates the virion uncoating. On the other hand, interactions with PDZD8 or CYPA stabilize the capsid.
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-2-LX572 | Anti-HIV (FAB25.3) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 | Human | FAB25.3 | Human | CD4-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX596 | Anti-HIV (13B5) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 | Human | 13B5 | Mouse | CD4-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX608 | Anti-HIV (CB4-1) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 | Human | CB4-1 | Mouse | CD4-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX655 | Anti-HIV (CB41) (CD4-scFv-h(CD28-CD3ζ)) CAR, pCDCAR1 | Human | CB41 | Mouse | CD4-scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX813 | Anti-HIV (FAB25.3) (CD4-scFv-h(4-1BB-CD3ζ)) CAR, pCDCAR1 | Human | FAB25.3 | Human | CD4-scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX837 | Anti-HIV (13B5) (CD4-scFv-h(4-1BB-CD3ζ)) CAR, pCDCAR1 | Human | 13B5 | Mouse | CD4-scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX849 | Anti-HIV (CB4-1) (CD4-scFv-h(4-1BB-CD3ζ)) CAR, pCDCAR1 | Human | CB4-1 | Mouse | CD4-scFv-4-1BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-T-2-LX896 | Anti-HIV (CB41) (CD4-scFv-h(4-1BB-CD3ζ)) CAR, pCDCAR1 | Human | CB41 | Mouse | CD4-scFv-4-1BB-CD3ζ | Lentiviral vector | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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