p53

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Associated Disease
  • Cancer
Anti-p53 TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-L088Z Human Human 8kb Lentiviral LLGRNSFEV Single-chain HLA-A2.1 Inquiry
TCR-L089 Human Human 8200bp retroviral vector LLGRNSFEV Single-chain TCR HLA-A2.1 Inquiry
TCR-L089Z Human Human 8kb Lentiviral LLGRNSFEV Non-modified HLA-A2 Inquiry
TCR-L090 Human Human 6700-8070bp retroviral vector LLGRNSFEV Non-modified TCR HLA-A2 Inquiry
TCR-L090Z Human Murinized (from Human) 8kb Lentiviral LLGRNSFEV Murinized HLA-A2 Inquiry
TCR-L091 Human Murinized (from Human) 6700-8070bp retroviral vector LLGRNSFEV Murinized TCR HLA-A2 Inquiry
TCR-L091Z Human Murinized (from Human) 8kb Lentiviral LLGRNSFEV Murinized and Cysteine-modified HLA-A2 Inquiry
TCR-L092 Human Murinized (from Human) 6700-8070bp retroviral vector LLGRNSFEV Murinized and Cysteine-modified TCR HLA-A2 Inquiry
TCR-L322 Human p-149 Human ~8kb Lentiviral STPPPGTRV Single-chain HLA-A2.1 Inquiry
TCR-L324 Human Human ~8kb Lentiviral LLGRNSFEV Single-chain HLA-A0201 Inquiry
CONTACT US

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Email:

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Tel: 44-207-097-1828

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