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This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
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| CAT | Product Name | Target Species | TCR Clone | Host Species | Epitope | Allele | Vector Type | Inquiry & Datasheet |
| TCR-L089 | Human anti-TP53 (LLGRNSFEV) T Cell Receptor, pSFG | Human | Human | LLGRNSFEV | HLA-A2.1 | retroviral vector | ||
| TCR-L090 | Human anti-TP53 (LLGRNSFEV) T Cell Receptor, pMSGV1 | Human | Human | LLGRNSFEV | HLA-A2 | retroviral vector | ||
| TCR-L091 | Murinized (from Human) anti-TP53 (LLGRNSFEV) T Cell Receptor, pMSGV1 | Human | Murinized (from Human) | LLGRNSFEV | HLA-A2 | retroviral vector | ||
| TCR-L092 | Murinized (from Human) anti-TP53 (LLGRNSFEV) T Cell Receptor[Cysteine-modified], pMSGV1 | Human | Murinized (from Human) | LLGRNSFEV | HLA-A2 | retroviral vector | ||
| TCR-L088Z | Human anti-p53 (aa264-272) T cell receptor (Single-chain TCR), pCDTCR1 | Human | Human | LLGRNSFEV | HLA-A2.1 | Lentiviral | ||
| TCR-L089Z | Human anti-p53 (aa264-272) T cell receptor, pCDTCR1 | Human | Human | LLGRNSFEV | HLA-A2 | Lentiviral | ||
| TCR-L090Z | Murinized anti-p53 (aa264-272) T cell receptor, pCDTCR1 | Human | Murinized (from Human) | LLGRNSFEV | HLA-A2 | Lentiviral | ||
| TCR-L091Z | Murinized anti-p53 (aa264-272) T cell receptor (Cysteine-modified), pCDTCR1 | Human | Murinized (from Human) | LLGRNSFEV | HLA-A2 | Lentiviral | ||
| TCR-L322 | Human anti-p53 T cell receptor (p-149), pCDTCR1 | Human | p-149 | Human | STPPPGTRV | HLA-A2.1 | Lentiviral | |
| TCR-L324 | Human anti-p53 T cell receptor, pCDTCR1 | Human | Human | LLGRNSFEV | HLA-A0201 | Lentiviral | ||
| TCR-LA-ZP004 | Anti-p53 (LLGRNSFEV) TCR-Like Antibody | Human | I3M2 | Human | LLGRNSFEV | HLA-A2 | ||
| TCR-LA-ZP105 | Anti-p53 (RMPEAAPPV) TCR-Like Antibody (T1-116C), HLA-A*0201-Restricted | Human | T1-116C | RMPEAAPPV | HLA-A*0201 | |||
| TCR-LA-ZP106 | Anti-p53 (RMPEAAPPV) TCR-Like Antibody (T1-29D), HLA-A*0201-Restricted | Human | T1-29D | RMPEAAPPV | HLA-A*0201 | |||
| TCR-LA-ZP107 | Anti-p53 (RMPEAAPPV) TCR-Like Antibody (T1-84C), HLA-A*0201-Restricted | Human | T1-84C | RMPEAAPPV | HLA-A*0201 | |||
| TCR-LA-ZP108 | Anti-p53 (GLAPPQHLIRV) TCR-Like Antibody (T2-108A), HLA-A*0201-Restricted | Human | T2-108A | GLAPPQHLIRV | HLA-A*0201 | |||
| TCR-LA-ZP109 | Anti-p53 (GLAPPQHLIRV) TCR-Like Antibody (T2-2A), HLA-A*0201-Restricted | Human | T2-2A | GLAPPQHLIRV | HLA-A*0201 | |||
| TCR-LA-ZP110 | Anti-p53 (GLAPPQHLIRV) TCR-Like Antibody (T2-116A), HLA-A*0201-Restricted | Human | T2-116A | GLAPPQHLIRV | HLA-A*0201 |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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