SSX2

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X.

Associated Disease
Anti-SSX2 TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C239Z Human TCR5 Human ~8kb Lentiviral KASEKIFYV Codon optimized HLA-A*0201 Inquiry
TCR-C240Z Human TCR5 Murinized ~8kb Lentiviral KASEKIFYV Codon-optimized and murinized HLA-A*0201 Inquiry
TCR-L106Z Human Murinized (from Human) 8kb Lentiviral KASEKIFYV Murinized HLA-A2 Inquiry
TCR-L107 Human Murinized (from Human) 6700-8070bp retroviral vector KASEKIFYV Murinized TCR HLA-A2 Inquiry
TCR-L262 Human Human ~8kb Lentiviral KASEKIFYV Non-modified HLA-A2 Inquiry
TCR-L263 Human Human ~8kb Lentiviral KASEKIFYV codon-optimized HLA-A2 Inquiry
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