Tat

Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR. Neurons are rarely infected, but they internalize Tat via their LDLR. Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression. Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors. Tat plays a role in T-cell and neurons apoptosis. Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.

Associated Disease
  • HIV-1 infection
Anti-Tat TCR Product list:
Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Type Epitope Format HLA Data
sheet
Price
TCR-C243Z HIV-1 c23  Human ~8kb Lentiviral ITKGLGISYGR Non-modified HLA-A68 Inquiry
TCR-L107Z HIV Human 8kb Lentiviral ITKALGISYGR Non-modified HLA-A68 Inquiry
TCR-L108 HIV Human 3111bp retroviral vector ITKGLGISYGR Non-modified TCR HLA-A68 Inquiry
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