Tissue factor

Tissue factor, also called platelet tissue factor, factor III, thromboplastin, or CD142 is a protein encoded by the F3 gene present in subendothelial tissue and leukocytes necessary for the initiation of thrombin formation from the zymogen prothrombin. Tissue factor (TF) is a transmembrane glycoprotein that is essential for hemostasis. It binds the coagulation serine protease factor VII/VIIa (FVII/VIIa) to form a bimolecular complex that functions as the primary initiator of coagulation in vivo. Many studies have shown that levels of circulating TF in the form of MPs are increased in various diseases, including cardiovascular disease, sepsis, diabetes, and cancer. TF is expressed by all types of cancers. Importantly, TF-dependent activation of coagulation has been implicated in cancer-associated thrombosis and metastasis.

Associated Disease
Anti-Tissue factor CAR Product list:
Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC288 T cell Second ~8kb Lentiviral Protein-41BB-CD3ζ Inquiry
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