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Tn-MUC1

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The MUC1 glycoprotein is a transmembrane epithelial mucin normally expressed on the apical surface of most simple glandular epithelial cells. In tumors, MUC1 is overexpressed and distributed all over the cell surface, aberrantly glycosylated, and shed in the tissue microenvironment. MUC1 expressed by breast cancer carries shortened O-glycans such as GalNAca1-O-Ser/Thr (Tn) or Galh1-3GalNAca1-O-Ser/Thr (T, core 1), which may be sialylated to give sialyl-Tn or sialyl-T. Tn glycoform of MUC1 (Tn-MUC1) is a neoantigen interconnected in various tumors. Hostile to Tn-MUC1 CAR T cells exhibited target-specific cytotoxicity and effectively controlled tumor development in xenograft models of T cell leukemia and pancreatic growth.

Tn-MUC1 Associated Disease
  • MUC1-expressing tumors
  • Others
  • CAR Vector Products

  • CAR Viral Particles

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-LC128 Anti-Tn-MUC1 (237) h(CD28-CD3ζ) CAR, pCDCAR1 Human 237 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC129 Anti-Tn-MUC1 (237) h(41BB-CD3ζ) CAR, pCDCAR1 Human 237 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-ZP3078 Anti-Tn-MUC1 (5E5) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5E5 Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP3079 Anti-Tn-MUC1 (5E5) h(41BB-CD3ζ) CAR, pCDCAR1 Human 5E5 Humanized scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP3080 Anti-Tn-MUC1 (3H4 ) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3H4  Humanized scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP3081 Anti-Tn-MUC1 (3H4 ) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3H4  Humanized scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
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