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Third Generation of CARs Design

As a leading provider of Chimeric antigen receptors (CARs) products, Creative Biolabs provides unparalleled CellRapeutics™ third generation CARs design to satisfy various customers' needs. We completely understand the challenge in constructing CARs. Thankfully, with an excellent and efficient team, and advanced techniques, we have successfully built up an solid platform for CARs construction.

Third Generation of CARs Design

From The Scientists. The CAR T-Cell Race by Vicki Brower on April 1, 2015.

Generally, the third generation CARs consist of an antigen binding unit, a spacer, a transmembrane domain and endodamain(s) the same as first or second-generations. The difference between the third generation and other generations is the co-stimulatory signaling domain, which composed of two different co-stimulatory signaling units in the intracellular regions besides the CD3ζ or FcεRIγ signaling domain. The major advantage of the third generation CARs is that it can induce high level cytokine secretion and significantly increase proliferation speed and survival rate of engrafted T cells. Our skilled scientists have constructed a variety of chimeric antigen receptors with signaling components such as CD28, CD137 (4-1BB), CD134 (OX40) and DAP10.

Creative Biolabs has established and developed world-renowned platform for CAR design, which can provide a superb service for every customer. With the solid reputation as a best-class services provider, we guarantee that CARs products from Creative Biolabs can greatly accelerate your project.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-048-3343

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