HSA-IFNα2b

Recombinant HSA fusion Interferon alpha-2b produced in P. Pichia is a single, non-glycosylated, polypeptide chain having a molecular mass of 85.7 kDa

At least 23 different variants of Interferon-alpha are known. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxyl-terminal end.

Lyophilized from a (3mg/ml) solution in containing 2.4mg Tris base and 8.8mg sodium chloride.

The specific activity as determined in a viral resistance assay using VSV-WISH cells was found to be 1.0 x 10⁶ IU/ mg.

Less than 0.1 ng/ug (IEU/ug) of HSA-IFN-alpha 2b.

It is recommended to reconstitute the lyophilized HSA-IFN alpha-2b in sterile 18MΩ-cm H₂O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

Lyophilized HSA-IFN alpha-2b although stable at room temperature for 3 weeks, should be stored desiccated below -18^oC. Upon reconstitution HSA-IFN alpha-2b should be stored at 4^oC between 2-7 days and for future use below -18^oC. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freeze-thaw cycles.

IFNA, INFA2, MGC125764, MGC125765, Leukocyte interferon, B cell interferon, Type I interferon, IFNA2, IFN-α 2a, Interferon alpha-A, LeIF A, Interferon alpha-2; Interferon alpha-2 Precursor.

Antigen processing and presentation; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; KEGG pathway: Natural killer cell mediated cytotoxicity; Regulation of autophagy; Toll-like receptor signaling pathway

interferon-alpha/beta receptor binding