HSP 90β

CRP0846

Recombinant Human heat shock protein 90β produced in E. coli has a molecular mass of approximately 85 KDa.

An approximately 90 kDa heat shock protein constitutively expressed in the cytoplasm. It exists as a dimer and has been observed to bind other cellular proteins such as p60v-src, steroid receptors, heme-regulated protein kinase, actin, and tubulin. Bind to histones with high affinity and induces chromatin condensation. Human recombinant HSP90β is expressed in E. coli.

>95% as determined by SDS-PAGE.

The biological activity of GDNF is measured by its ability to support survival and stimulate neurite outgrowth of cultured embryonic chick dorsal root ganglia. Activity can also be measured by its ability to bind recombinant human GFRα1/Fc.

Liquid. In PBS Buffer. Avoid freeze/thaw cycles.

Gene Name

HSP90B1

Synonyms

ECGP; GP96; GRP94; TRA1; 94 kDa glucose-regulated protein; Endoplasmin precursor; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; Tumor rejection antigen-1 (gp96); endothelial cell (HBMEC) glycoprotein; glucose regulated protein; 94 kDa; gp96 homolog; heat shock protein 90kDa beta (Grp94), member 1; tumor rejection antigen (gp96) 1

GeneID

7184

mRNA Refseq

NM_003299.1

Protein Refseq

NP_003290.1

MIM

191175

Uniprot ID

O95433

Chromosome Location

12q24.2-q24.3

Function

ATP binding, RNA binding, calcium ion binding, low-density lipoprotein receptor binding, nucleotide binding, unfold protein binding, virion binding.

Process

anti-apoptosis, protein folding, protein transport, response to hypoxia, sequestering of calcium ion.