HSP90β Fragment 2

Heat Shock Protein 90β Fragment 2 [back] PRICE INQUIRY

Cat. No.

CRP0847

Product overview

Recombinant Human HSP90β Fragment 2 produced in E. coli has a molecular mass of approximately 54 KDa.

Description

HSP90β Fragment 2 is the middle domain and c-terminal of HSP90β, it is his-tagged and expressed in E. coli.

Purity

>95% as determined by SDS-PAGE.

Specific Activity

The biological activity of GDNF is measured by its ability to support survival and stimulate neurite outgrowth of cultured embryonic chick dorsal root ganglia. Activity can also be measured by its ability to bind recombinant human GFRα1/Fc.

Storage buffer

Liquid. In PBS Buffer. Avoid freeze/thaw cycles.

Gene Information

Gene Name

HSP90B1

Synonyms

ECGP; GP96; GRP94; TRA1; 94 kDa glucose-regulated protein; Endoplasmin precursor; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; Tumor rejection antigen-1 (gp96); endothelial cell (HBMEC) glycoprotein; glucose regulated protein, 94 kDa; gp96 homolog; heat shock protein 90kDa beta (Grp94), member 1; tumor rejection antigen (gp96) 1

GeneID

mRNA Refseq

Protein Refseq

MIM

Uniprot ID

Chromosome Location

12q24.2-q24.3

Function

ATP binding, RNA binding, calcium ion binding, low-density lipoprotein receptor binding, nucleotide binding, unfold protein binding, virion binding.

Process

anti-apoptosis, protein folding, protein transport, response to hypoxia, sequestering of calcium ion.

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Domain structure of the yeast heat-inducible Hsp90. Top: 3D structure of the dimeric Hsp90 based on PDB 2CG9 coordinates. Bound ATP molecules are represented by space filling spheres. Bottom: 1D sequence of the yeast Hsp90. NTD= N-terminal domain (red), MD = middle domain (green), CTD = C-terminal domain (blue).