| Cat. No. |
CRP08109 |
| Product Overview |
Recombinant Human
Lymphotactin produced in E. coli is a single, non-glycosylated
polypeptide chain containing 92 amino acids and having a molecular
mass of 10.0 kDa. |
| Description |
Lymphotactin is the
only known member of the C-chemokine family and signals through the
receptor XCR1, formally known as GPR5. The spleen shows the highest
level of lymphotactin compared to peripheral leukocytes, lung, colon
and small intestine. Lymphotactin is chemotactic towards lymphocytes
but not towards monocytes or neutrophils. |
| Purity |
>97% by SDS-PAGE
and HPLC analyses. |
| Formulation |
Lyophilized from a
0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH7.4,
150mM NaCl. |
| Specific Activity |
Fully biologically
active when compared to standard. Determined by its ability to
chemoattract human T cells using a concentration range of 10.0-100.0
ng/ml. |
| Endotoxin |
Less than 1EU/mg of
rHuXCL1 as determined by LAL method. |
| Reconstitution |
We recommend that
this vial be briefly centrifuged prior to opening to bring the
contents to the bottom. Reconstitute in sterile distilled water or
aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0
mg/ml. Stock solutions should be apportioned into working aliquots
and stored at <-20°C. Further dilutions should be made in
appropriate buffered solutions. |
| Storage |
This lyophilized
preparation is stable for several weeks at 2-8°C, but should be kept
at -20°C for long term storage, preferably desiccated. Upon
reconstitution, the preparation is stable for up to one week at
2-8°C. For maximal stability, apportion the reconstituted
preparation into working aliquots and store at -20°C to -70°C. Avoid
repeated freeze/thaw cycles. |
| Gene Information |
Gene Name |
XCL1 |
|
Synonyms |
LTN; ATAC; LPTN;
SCM1; SCM-1; SCYC1; SCM-1a; chemokine (C motif) ligand 1;
lymphotactin; XCL1_HUMAN; Lymphotactin [Precursor]; C motif
chemokine 1;Cytokine SCM-1;SCM-1-alpha;Small-inducible cytokine
C1;XC chemokine ligand 1. |
|
GeneID |
6375 |
|
mRNA Refseq |
NM_002995 |
|
Protein Refseq |
NP_002986 |
|
MIM |
600250 |
|
UniProt ID |
P47992 |
|
Chromosome Location |
1q23 |
|
Pathway |
Cytokine-cytokine receptor interaction. |
|
Function |
chemokine activity |
|
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