| Cat. No. |
CRP0853 |
| Product Overview |
Recombinant Human
β-Nerve Growth Factor produced in E. coli has a molecular mass
of 13,267.1 Da. |
| Description |
Nerve Growth
Factor is the first of a series of neurotrophic factors that
were found to influence the growth and differentiation of
sympathetic and sensory neurons. It is comprised of alpha, beta,
and gamma subunits. The beta subunit is responsible for its
growth stimulating activity. The synthesis of NGF in astrocytes
is enhanced by various other cytokines: IL-1, TNF-alpha, PDGF
and TGF-beta. Human recombinant nerve growth factor is expressed
in E. coli. |
| Purity |
≥95% as
determined by SDS-PAGE. |
| Component |
rh-Nerve Growth
Factor-β, NaAc 30 mM, pH 5.5 |
| PI |
8.81 by
Isoelectricfocusing |
| concentration |
0.5mg/ml by BCA |
| Specific Activity |
The activity
essay was measured in culture using the PC-12 cell line. |
| Endotoxin |
less than 10EU/mg
as determined by LAL method |
| Storage Buffer
|
Liquid. In PBS
Buffer. |
| Storage |
At 4℃ for 6
months and -80℃ for 2 years |
| Gene
Information |
Gene Name |
NGF |
|
Synonyms
|
Beta-NGF; HSAN5;
MGC161426; MGC161428; NGFB; Beta-nerve growth factor precursor;
beta-nerve growth factor; nerve growth factor, beta polypeptide;
nerve growth factor, beta subunit;NGF_HUMAN. |
|
GeneID |
4803 |
|
mRNA Refseq |
NM_002506 |
|
Protein
Refseq |
NP_002497 |
|
MIM |
162030 |
|
UniProt ID |
P01138 |
|
Chromosome
Location |
1p13.1 |
|
Pathway |
Apoptosis, MAPK
signaling pathway, Signalling by NGF |
|
process |
Ras
protein singnal transduction, nerve growth factor processing,
peripheral nervous system development, positive regulation of
axon extension. |
|
Function |
growth factor
activity, nerve growth factor receptor binding, receptor
signaling protein activity |
|
|
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