PDGF-BB

CRP0855

Recombinant Human Platelet-Derived Growth Factor-BB produced in E. coli has a molecular mass of 27KD.

Platelet-Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue. PDGF which is composed of a dimer of two chains termed the A chain and B chain, can be present as AA or BB homodimers or as an AB heterodimer. Recombinant human PDGF-BB is a24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids). Human recombinant platelet-derived growth factor is expressed in E. coli.

≥95% as determined by SDS-PAGE.

9.39 by Isoelectricfocusing

1 mg/ml by BCA

Platelet-Derived Growth Factor-BB, PBS buffer, pH 7.4

less than 10EU/mg as determined by LAL method

Liquid. In PBS Buffer.

At 4℃ for 6 months and -80℃ for 2 years

Gene Name

PDGFB

Synonyms

FLJ12858; PDGF2; SIS; SSV; c-sis; Becaplermin; PDGF-2; SIS; SSV; becaplermin; c-sis; HUMANES PDGF-B GEN AUS PGEM2-PDGF-B, FLANKIERT VON 5'-ECORI UND3'-HINDIII RESTRIKTIONSSCHNITTSTELLEN;PDGFB_HUMAN;PDGF B-chain; PDGF, B chain; PDGF-B VORLAEUFERSEQUENZ; Platelet-derived growth factor B chain precursor; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor, beta polypeptide (oncogene SIS); oncogene SIS ; platelet-derived growth factor 2; platelet-derived growth factor beta; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor, B chain; v-sis platelet-derived growth factor beta polypeptide (simian sarcomaviral oncogene homolog).    

GeneID

5155    

mRNA Refseq

NM_002608

Protein Refseq

NP_002599

MIM

190040

UniProt ID

P01127

Chromosome Location

22q12.3-q13.1; 22q13.1

Pathway

Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma.

Function

cell surface binding, growth factor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein binding, protein heterodimerization activity, protein homodimerization activity.