|
Cat. No. |
CRP0857 |
|
Product overview |
Recombinant Human PEX produced in E. coli has a molecular
mass of approximately 23 KDa. |
|
Description |
PEX is
the C-terminal hemopexin domain of Matrix Metalloproteinase-2. It
has the activity of anti-angiogenesis, and a naturally occurring
form of PEX can be detected in vivo. PEX can block angiogenesis and
tumor growth in vivo, providing a potentially novel therapeutic
approach for diseases associated with neovascularization. The
appearance of PEX at sites of neovascularization may not only
control normal angiogenesis, but when administered in sufficient
quantities, may provide a naturally-occurring therapeutic inhibitor
of diseases associated with angiogenesis. |
|
Purity |
>95%
as determined by SDS-PAGE. |
|
Specific Activity |
Measured by its ability of suppressing angiogenesis in vitro. |
|
Formulation |
The
protein (1mg/ml) was lyophilized with 2mM Tris pH-7.4. |
|
Storage buffer |
Liquid. In PBS Buffer. |
|
Storage |
Lyophilized rHuPEX although stable at room temperature for 3 weeks,
should be stored desiccated below -18°C. Upon reconstitution rHuPEX
should be stored at 4°C between 2-7 days and for future use below
-18°C.For long term storage it is recommended to add a carrier
protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
|
Gene Information
|
Gene Name |
MMP2 |
|
Synonyms |
CLG4; MONA; CLG4A; TBE-1; MMP-II; matrix metallopeptidase 2 (gelatinase
A, 72kDa gelatinase, 72kDa type IV collagenase); matrix
metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV
collagenase); MMP2_HUMAN; 72 kDa type IV collagenase [Precursor]; EC
3.4.24.24.; 72 kDa
gelatinase; 72kD type IV collagenase; Gelatinase A; Matrix
metalloproteinase-2; collagenase type IV-A; matrix metalloproteinase
2 (gelatinase A, 72kD gelatinase, 72kD typeIV collagenase); matrix
metalloproteinase-II; neutrophil gelatinase. |
|
GeneID |
4313 |
|
mRNA Refseq |
NM_001127891 |
|
Protein Refseq |
NP_001121363 |
|
MIM |
120360 |
|
Uniprot ID |
P08253 |
|
Chromosome Location |
16q13-q21 |
|
pathway |
GnRH signaling pathway; Leukocyte transendothelial migration.
|
|
Function |
calcium ion binding;
catalytic activity;
metal ion binding;
metalloendopeptidase activity;
protein binding;
zinc ion binding. |
|
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