nKHC

CRP0848

Recombinant Human N-Terminal Fragment of Kinesin Heavy Chain produced in E. coli has a molecular mass of approximately 30 KDa.

The kinesin family of motor proteins comprises at least two forms of conventional kinesin, and they are encoded by different genes and designated as ubiquitous kinesin, which is expressed in all cells and tissues, and neuronal kinesin, which is expressed exclusively in neuronal cells. While the kinesin heavy chain contains motor activity, evidence suggests that the kinesin light chain is involved in either modulation of kinesin heavy chain activity or in cargo binding. The motor protein kinesin is a heterotetramer composed of two heavy chains of approximately 120 kDa and two light chains of approximately 65 kDa. Kinesin motor activity is dependent on the presence of ATP and microtubules. rh-nKHC is a N-terminal fragment of uKHC with a histidine-tagged expressed in E. coli.

>95% as determined by SDS-PAGE.

Inclusion Body.

Gene Name

KIF2A

Synonyms

HK2; KIF2; KNS2; Kinesin-2; Kinesin, heavy chain, 2; Kinesin-like protein KIF2A; kinesin heavy chain member 2; kinesin heavy chain member 2A    

GeneID

3796

mRNA Refseq

NM_001098511.1

Protein Refseq

NP_001091981.1

MIM

602591

Uniprot ID

O00139

Chromosome Location

5q12-q13

Function

ATP binding, microtubule motor activity, nucleotide binding

Process

cell differentiation, microtubule-based movement, multicellular organismal development, nervous system development