Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCreative Biolabs is constantly focusing on discovery and development of impeccable therapeutic antibodies for our global customers. We now provide professional service of human antibody production using transgenic mice/rats by hybridoma technique.
Transgenic mice derived from genetically engineered mouse embryonic cell lines with heterologously introduced human Ig transloci and silenced endogenous mouse Ig genes (designed zinc finger nuclease). Therefore, the resulting mice can produce fully human antibodies once challenged with antigens. Mouse constant regions will mostly remain the same to allow for efficient B cell maturation. This technology has long been considered a promising solution for human antibody development, gaining increasing attention during recent years. In comparison with alternative approaches like humanization, premade antibody screening, transgenic mice have several attractive features:
Creative Biolabs has established a well-recognized Magic™ humanized mice/rats platform that integrates multiple best-class transgenic mice/rats resources around the world. Incorporated with our powerful antibody development techniques, we have three ways to harvest high specific, high-affinity antibody candidates from immunized transgenic animals: hybridomas, phage display immune library screening, and plasma cell sorting. Of these three methods, hybridomas represent the most classic approach. With the help of our Omni-Hybridoma™ Platform, scientists in Creative Biolabs are confident in isolating high-quality monoclonal antibodies within only 70 days. Immunogens can be prepared in various formats using our proprietary Magic™ adjuvant. This way, strong and potent immune responses can be guaranteed, which is the key to success. Of note, we can generate both mouse and rat hybridomas. Generally, to use mouse/rat from different background simultaneously can greatly facilitate the chance to find the best antibody clone, as the immune reactions may vary in different species.
As alternatives, Creative Biolabs also offers transgenic phage display immune library technology and Native plasma cell sorting strategies, which have proved highly efficient and reliable in antibody generation as well. In addition to conventional VH-VL antibodies, human sdAbs can also be derived from one specialty mouse strain. Our seasoned research staffs are always willing to discuss with our clients on “case-to-case” basis, and tailor custom-oriented project plan to satisfy every specific demand. Please feel free to inquiry us for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
