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Monoclonal Mouse Antibody Production

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Monoclonal Mouse Antibody Production Creative Biolabs provides the best mouse monoclonal antibody production service for our customers all over the world. With the extensive expertise in the field of phage display technology, our scientists are pleased to construct high quality immunized mouse antibody libraries and screen out high affinity monoclonal mouse antibodies.

Mice, as one of the most common rodents, are widely used as basic laboratory animals in various researches, especially in biology, psychology and medicine fields. This species is well-recognized as a kind of mammalian model organism, because of the fully sequenced genome, obviously high gene homology with human and high reproduction rate. Compared with other familiar experimental animals, mice take advantages of their small size, lower feeding cost, ease of maintenance and handling and strong ability to reproduce. Moreover, the genetic research of mice is comparatively mature and there are hundreds of established inbred, outbred and transgenic lines of mice for different experimental studies. For example, BALB/c mouse is one of the main strains used in the research of cancer and immunology.

For antibody discovery, mice are one of the most important sources. They produce similar antibody isotypes with human, including IgA, IgD, IgE, IgG and IgM. Compared with the subclasses of human antibody isotypes, mice contain only one IgA class and the IgG subclasses are known as IgG1, IgG2a, IgG2b and IgG3. In addition, laboratory mice can induce a good immune response to a great range of antigens, even those highly homological human proteins. Moreover, some treatments that unacceptable for humans can also be aboveboard applied for mice with results which are analogous to that from humans. Therefore, the development of mouse monoclonal antibodies is a common choice for a variety of therapeutics and pathology researches. Up to now, the rapid development of therapeutic antibody in the pharmaceutical industry has enabled the mice to play an important role in both monoclonal antibodies discovery and the pre-clinical assessment.

In the field of antibody development, Creative Biolabs is a well-known expert who can use the phage display antibody libraries to produce mouse monoclonal antibodies with high affinity and specificity. Through routine immunization strategy, immunized mouse antibody libraries can be generated with high diversity by our advanced phage display technology. And several high affinity antibodies can then be selected through biopanning techniques. As alternative, Creative Biolabs also provides the unique Native™ Antibody Discovery Platform, which based on antigen-specific B lymphocytes cytometry technology, to substitute phage display platform for Native™ Mouse Antibody Discovery.

Creative Biolabs has years of experience in the research and development of antibody. Our scientists are confident in producing high affinity monoclonal antibodies to meet our clients’ most specific requirement and facilitate their projects.




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