Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe first trifunctional antibody successfully produced from quadromas is catumaxomab. At first, mouse hybridoma cells whose monoclonal antibodies target one of the desired antigens are produced. Independently, rat hybridoma cells targeting the other antigen are produced. Then, these two cell types are hybridized, yielding hybrid-hybridomas or quadromas, which produce hybrid (trifunctional) antibody as well as pure mouse and pure rat antibody. The trifunctional antibody is extracted chromatographically with protein A.
The disadvantage of quadromas is the produced antibodies are a mixture. Especially if these two hybridoma cells are the same species, up to ten different kinds of antibody can be produced, most of which have mismatched heavy or light chains, or both. Fig. 1 below presents the possible combinations of light- and heavy-chains in antibodies produced by quadroma cell lines.
Fig. 1 Antibodies
produced by quadroma cell lines. The seven antibodies on the left have at least
one mismatched binding region. Of the three antibodies on the right, two are
not hybridized, and the remaining (rightmost) is the desired trifunctional
antibody.
Scientists in Creative Biolabs have successfully established the method to produce custom bispecific antibody according to client's requirement. If interested, please contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
