3D Ex Vivo Human Bone Tissue Model Introduction

Bone is a vital tissue, mainly composed of collagen and calcium, which performs a crucial function in protecting soft organs and supporting the body. In general, the development of bone therapeutic strategies starts with preclinical testing, including in vitro experiments in animal models and in vivo studies. Ex vivo models contribute to supplementing the development process. As a reputable supplier of ex vivo human bone tissue models, Creative Biolabs understands your bone research sample needs. With our ability to ethically collect diseased biospecimens as well as normal human biospecimens, we are your trusted partner for the research on skeletal mechanisms and the development of preclinical therapeutic strategies.

Fig 1. Development process for novel therapies related to bone.¹

Shortcomings of Common Models

Cell models and animal models are very attractive tools in the development of new treatments for damaged and diseased bones. However, both models come with some drawbacks. For cellular models, most cell culture systems lack the proper extracellular matrix, cellular diversity and natural spatial distribution of bone microenvironment components. Consequently, the results are not reliable due to the missing complexity of the natural skeletal environment. Although animal models can reflect the complex environment in the body, they are generally time-consuming, expensive and involve ethical issues.

Advantages of Ex Vivo Models

3D ex vivo human bone tissue models are a promising alternative that bypasses the limitations of cell and animal models.

• The innate ratio of different osteocytes is maintained in bone organ cultures.
• The ex vivo model preserves the cellular diversity and spatial distribution of bone, which allows for the study of cell-cell interactions in the local bone microenvironment in a controlled experimental setting.
• Compared with animal models, ex vivo models represent a less costly screening model.
• Ex vivo models are useful to address ethical issues related to animal testing.
• The establishment of bone tissue ex vivo models can complement the preclinical testing process.
• Ex vivo models reproduce human conditions and are effective tools for testing patient response to therapeutic agents.
• Ex vivo models allow the prediction of in vivo responses to genetic and pharmacological interventions, which is beneficial in saving valuable time and resources.

Applications of 3D Ex Vivo Human Tissue Model

These ex vivo models provide a powerful platform for the study of bone physiology and pathophysiology. Ex vivo bone models are closely related to the study of bone biology, including bone growth, bone and cartilage matrix turnover, response to treatment, genetic manipulation, mechanical loading, and the role of cancer cells in bone. In conclusion, ex vivo models are indispensable tools for revealing molecular mechanisms of cell and bone biology and for rapid screening of drugs and therapies.

Fig.2 Applications of ex vivo bone tissue models. (Creative Biolabs)

Creative Biolabs is a global leader in providing human ex vivo tissue models to researchers in the life sciences and pharmaceuticals. We are committed to providing the highest quality 3D ex vivo human bone tissue model as well as 3D ex vivo human cartilage tissue model to assist your preclinical drug development. Please feel free to contact us to discuss your project for professional assistance.

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• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model