3D Ex Vivo Human Cartilage Tissue Model Introduction

Cartilage is an important connective tissue that plays a vital role in protecting joints and bones. Several inflammatory rheumatic diseases cause arthritis and can severely damage cartilage tissue. Inadequate understanding of pathogenesis and challenges in drug delivery due to the avascular nature of adult cartilage have hampered the development of treatments for cartilage diseases. Successful drug discovery relies on a solid foundation that drives effective clinical translation. Creative Biolabs has laid this foundation with high-quality human ex vivo cartilage tissue models.

Significance of Ex Vivo Models

Various models are used to study cartilage-related diseases, especially osteoarthritis (OA). Each model has its own pros and cons.

Furthermore, to overcome the obstacle in the treatment of OA, a new evaluation system for cartilage-targeted drug delivery is highly necessary. Ex vivo human cartilage tissue models offer new insights into the study of cartilage pathogenesis and the development of new therapeutic strategies.

Advantages of Ex Vivo Human Cartilage Models

• These models allow the preservation of cell-cell and cell-matrix interactions, which contribute to a better understanding of how cells behave in their natural three-dimensional environment.
• In the ex vivo tissue model, the cells are located in natural extracellular matrices (ECM). Therefore, the model provides an effective tool for evaluating drug permeability and action.
• Ex vivo models can fill the gap that exists between the complexity of the in vivo environment and the simplicity of the in vitro condition.
• Ex vivo models are tools for studying physiological and pathological processes in a controlled environment, resulting in more realistic and reliable results.

Fig 1. Osteochondral explant harvesting and culture system.¹

Applications of Ex Vivo Models

Ex vivo models are powerful tools for cartilage research. They can closely mimic processes in the body, playing a crucial role in the study of cartilage responses to specific stimuli. In addition, ex vivo models are helpful to study the mechanism of cartilage matrix turnover and advance the understanding of cartilage physiology. Importantly, the ex vivo model represents a valuable preclinical tool for studying the regenerative potential for clinically relevant cartilage therapy. Notably, this model allows the study of chondrocyte proliferation and differentiation under nearly in vivo conditions.

Fig.2 Multiple applications of ex vivo models. (Creative Biolabs)

With a network of hospitals and organ procurement organizations across the country, Creative Biolabs focuses on providing high-quality ex vivo human cartilage tissue models as well as 3D ex vivo human bone tissue models to meet the needs of customers. With the increasing acceptance of our ex vivo models by customers, Creative Biolabs has become a world-renowned biological brand. Please contact us for details regarding ex vivo models.

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model