3D Ex Vivo Human Ovary Mixed Epithelial Tumor Model Introduction

While ovarian mixed epithelial tumor (OMET) is rare, their impact on patients and clinical challenges cannot be overlooked. To assist clients in overcoming the limitations of current treatment methods and accelerating the development of novel drugs, Creative Biolabs offers a 3D ex vivo human OMET model for global researchers.

Introduction to Ovarian Mixed Epithelial Tumors (OMET)

Definition: Ovarian mixed epithelial tumors encompass five histological types, including serous tumors, mucinous tumors, endometrioid tumors, clear cell tumors, and transitional cell tumors. OMET is a heterogeneous tumor composed of two or more of these ovarian epithelial tumor types.

Incidence: Rare, predominantly occurring in middle-aged and older women.

Reported OMETs: Mixture of endometrioid and clear cell tumors, mixture of serous tumors and endometrioid carcinoma, mixture of serous tumors and transitional cell tumors, mixture of mucinous tumors and transitional cell tumors, borderline tumors (mixture of serous and mucinous tumors).

Risk Factors: Endometriosis.

Diagnostic Methods: Immunohistochemistry, Hematoxylin-eosin Staining, Magnetic Resonance Imaging.

Clinical Manifestations: Abdominal distension, pelvic mass.

Tumor Characteristics: OMET typically occurs in a unilateral ovary. It is generally cystic with septations and fluid, often accompanied by hemorrhage.

Occurrence Mechanisms: The exact pathogenesis of OMET remains unclear and requires further investigation.

Fig 1. Immunofluorescent analysis of E-cadherin and Vimentin expression in ovarian cancer cells. Fig 1. TRPM7 silencing inhibits the epithelial-mesenchymal
transition (EMT) in ovarian cancer cells.¹

3D Ex Vivo Human OMET Model: A Tool for Drug Development

Currently, the treatment of OMET primarily involves surgical resection followed by adjuvant radiation therapy. However, this treatment approach cannot completely prevent tumor metastasis and recurrence. Creative Biolabs offers services for 3D ex vivo human OMET models, aiming to provide researchers with a more realistic and reliable tool to study and address the therapeutic challenges associated with OMET.

High Authenticity: Compared to traditional cell line models and animal models, this model can provide OMET cells and the tissue microenvironment that closely resemble the human body, making drug development more representative of real-world conditions.
High Predictability: This model enables more accurate prediction of drug efficacy, as it offers a more complex and biologically relevant cellular behavior and drug response patterns.

High-throughput Drug Screening and Evaluation: This model can be used for high-throughput drug screening, evaluating the anti-tumor activity of various candidate drugs against OMET, and aiding in the identification of potential therapeutic agents.
Drug Mechanism Studies: By simulating the tissue structure and microenvironment of OMET, this model can be employed to study the mechanisms of action, signaling pathways, and cellular responses of drugs, facilitating a deeper understanding of the interaction between drugs and tumors.
Personalized Treatment Research: Based on patient-derived samples, this model can be utilized to assess individual patients' response to specific drugs, providing guidance for the development of personalized treatment strategies.

Research Services Based on 3D Ex Vivo Human OMET Model at Creative Biolabs

Model Sourcing
Appropriate tumor tissue is obtained from licensed human OMET tissue through slicing, tissue dissociation, or other methods.
Model Construction
The isolated tumor tissue is implanted into a 3D structure using suitable techniques and carriers such as scaffolds and gels.
Model Culturing and Maintenance
Optimal culturing conditions, including temperature, humidity, and composition of the culture medium, are provided to facilitate the stable growth and functionality of the model.
Administration or Other Treatments
The model is treated with candidate drugs or other substances at specified concentrations according to the client's requirements.
Model Evaluation
The response of the model is assessed using various techniques and methods such as cell viability assays, morphological observations, and immunohistochemical staining.

Creative Biolabs is a renowned biotechnology company known for its exceptional research capabilities and innovative solutions. By offering 3D ex vivo human OMET models and other ovarian tissue models, we assist clients in better drug development and addressing the challenges faced in OMET treatment. If you are seeking a reliable partner to construct and utilize 3D ex vivo models, Creative Biolabs is the ideal choice. Please contact us to explore innovative solutions and embark on a successful journey in drug development.

*3D Ex Vivo* Human Ovary Tissue Model**
Human Ovary Adenocarcinoma Model	Human Ovary Brenner Tumor Model	Human Ovary Clear Cell Adenocarcinoma Model
Human Ovary Clear Cell Adenocarcinoma Model	Human Ovary Cystadenocarcinoma Model	Human Ovary Dysgerminoma Model
Human Ovary Fibroma Model	Human Ovary Granulosa Cell Tumor Model	……

Reference

Liu, L.; et al. TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling. J Exp Clin Cancer Res. 2019, 38: 106. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping part (C).

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