Gastric Motility

Creative Biolabs offers gastric motility assay services, enabling in-depth evaluation and identification of anomalous patterns and physiological processes within the stomach.

Gastric Motility Assays

The stomach performs vital functions, including accommodating and temporarily storing food, triturating and mixing it with secretions, and orderly emptying of food into the small intestine. Diverse methodologies are available for quantifying gastric motility. Gastric emptying (GE) tests are employed to assess gastric motility disorders, the assessments comprise measurements of following tests:

	Content	Application	Advantages	Disadvantages
Gastric Emptying Scintigraphy (GES)	In experimental animal studies, the measurement of GE involves the ingestion of a radiolabeled meal. The radioactivity quantified in the stomach is directly proportional to the volume of meal that remains in the stomach.	Diagnosing gastroparesis. (defined as gastric retention >10% at 4 h)	Widely admitted. Conventional motility standard.	Lacking pressure mapping.
Wireless Motility Capsules (WMC)	WMC is a non-digestible, single-use device ingested orally, designed to measure pH, pressure, and temperature at various points along the gastrointestinal (GI) tract.	WMC in diagnosing gastrointestinal symptom complexes arising from suspected transit abnormalities.	Pressure mapping. Measure GET, SBTT, etc; Noninvasive means.	Not widely available.
Gastric Emptying Breath Test (GEBT)	Also called ¹³C breath tests, Gastric emptying can be evaluated using a test meal labeled with a stable (nonradioactive) isotope (¹³C). The ¹³C-labeled substrate is absorbed and assimilated into the body's bicarbonate pool, eventually excreted via the lungs as ¹³CO₂.	The ¹³C-Spirulina platensis GEBT intended for assessing GE of solid substances.	No radiation involved. Simple & easy. Adapted to a variety of scenarios.	Not available for clinical use.

A graph illustrating the motility sample data obtained from a wireless motility capsule. Fig 1. A sample motility graph showing data from a wireless motility capsule.^1,3

Gastric Motility Disorders

Dysmotility, or the impairment of motility, this phenomenon constitutes the basis for various gastrointestinal disorders.

Delayed Gastric Emptying (gastroparesis)	Rapid Gastric Emptying (dumping syndrome)	Functional Dyspepsia
A delay in GE without the presence of mechanical obstruction at the gastric outlet.	Partially digested food attracts surplus fluid into the small intestine, leading to symptoms such as nausea, diarrhea, etc.	A term used to describe recurrent symptoms of gastric discomfort without apparent underlying etiology.

Planar images depicting gastric emptying were projected at five time points. Fig 2. Planar images of gastric emptying projected before and after at five time points: 0 (immediately after ingestion), 1, 2, 3 h.^2,3

Other Gastrointestinal Motility Assays

Creative Biolabs has developed a comprehensive array of platforms to assess the impact of drugs on the gastrointestinal system. Encompassing a diverse array of gastric motility assay approaches and high-quality 3D models, our platform serves as a pivotal tool in enhancing drug safety assessment, providing invaluable support to our esteemed clientele. The spectrum of models we offer encompasses, but is not confined to:

Please contact us to accelerate your gastrointestinal research.

References

Mosley, Liana et al. "What Is Wrong With This Wireless Motility Capsule?." ACG case reports journal. 9,5 (2022): e00768.
Qutbi, Mohsen et al. "Gastric Emptying Scintigraphy: Diagnostic Value of Delayed Imaging and the Impact on Reclassification of Diagnosis." Molecular imaging and radionuclide therapy. 32,2 (2023): 117-122.
Distributed under Open Access license CC BY 4.0, without modification

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