Creative Biolabs has developed a micro-physiological heart-liver body-on-a-chip model with a skin surrogate for testing drug toxicity associated with transdermal drug delivery. Our new technological finding ultimately could assist in the design of experimental trial protocols and reduce the cost, time, and labor of drug development.
An electrical connector was used to interface the microelectrode array to an external amplifier and stimulation system.
Fig 1. Schematic of the Heart-Liver body-on-a-chip system
with skin module containing. (Pires de Mello, 2020)
The multi-organ-on-a-chip models have significant potential in the drug discovery process and development. The heart-liver-skin three-organ-on-a-chip model in Creative Biolabs can be used to evaluate drug candidates at an early stage, enabling a high-content analysis of the mode of action of substances in a near-physiological cellular environment.
The heart-liver-skin three-organs-on-a-chip model of Creative Biolabs has overcome a variety of limitations and detailly demonstrates the inclusion of skin and other barrier tissues in a functional multi-organ system. It can be simultaneously used for the assessment of potential drug toxicity from dermal absorption and evaluate transport dynamics through the skin. Our model integrates multi organs such as the heart, liver, and skin, which enables you to evaluate the toxicity and effect of drugs in these important tissues. View our website for more organ-on-a-chip models.
Creative Biolabs is a global biotechnology enterprise that remains at the forefront of cutting-edge advancements. Our commitment extends to providing an array of dependable services, as listed below, which are curated to address the distinct research needs of our clientele around the world. if you would like to delve deeper into our versatile organs-on-a-chip models and the potential synergy with our supporting assays to accelerate your research, please contact us for more information.
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