Heart-Liver-Skin Three-Organs-on-a-Chip Model Introduction

Creative Biolabs has developed a micro-physiological heart-liver body-on-a-chip model with a skin surrogate for testing drug toxicity associated with transdermal drug delivery. Our new technological finding ultimately could assist in the design of experimental trial protocols and reduce the cost, time, and labor of drug development.

Construction of Our Heart-Liver-Skin Three-organs-on-a-chip Model

  • The Liver module on a coverslip.
  • Cardiomyocytes on bioMEMS cantilevers.
  • Cardiomyocytes on a microelectrode array.
  • Skin module.

An electrical connector was used to interface the microelectrode array to an external amplifier and stimulation system.

Fig 1. Diagrams of organ on chip platform. (Sunildutt, et al., 2023)Fig 1. Schematic of the Heart-Liver body-on-a-chip system
with skin module containing. (Pires de Mello, 2020)

Advantages of Our Heart-Liver-Skin Three-organ-on-a-chip Model

  • Real-time assessment of cardiac organ function.
  • Efficiently evaluates the toxicity of topically administrated drugs to the human heart and liver tissues.
  • The higher success rate of compounds that make it to regulatory approval.
  • Compared to traditional 3D culture, our chip provides a more precise recreation of organs' physiology.
  • Precise control of the multi-organ microenvironment.
  • Having the capability to reiterate the heterogeneous nature of the skin which can influence the permeation rate of the medication

Applications of Heart-Liver-Skin Three-organs-on-a-chip Mode

The multi-organ-on-a-chip models have significant potential in the drug discovery process and development. The heart-liver-skin three-organ-on-a-chip model in Creative Biolabs can be used to evaluate drug candidates at an early stage, enabling a high-content analysis of the mode of action of substances in a near-physiological cellular environment.

  • Manifesting revitalized cell discrepancy, cell-cell and cell-matrix interactions, and cell morphologies.
  • Allows the study of the systemic responses of several organs to the candidate drug.
  • Predicted drug toxicity efficiently not only from acute drug exposure but also from chronic drug treatment.

Why Choose Us?

The heart-liver-skin three-organs-on-a-chip model of Creative Biolabs has overcome a variety of limitations and detailly demonstrates the inclusion of skin and other barrier tissues in a functional multi-organ system. It can be simultaneously used for the assessment of potential drug toxicity from dermal absorption and evaluate transport dynamics through the skin. Our model integrates multi organs such as the heart, liver, and skin, which enables you to evaluate the toxicity and effect of drugs in these important tissues. View our website for more organ-on-a-chip models.

Related Services

Creative Biolabs is a global biotechnology enterprise that remains at the forefront of cutting-edge advancements. Our commitment extends to providing an array of dependable services, as listed below, which are curated to address the distinct research needs of our clientele around the world. if you would like to delve deeper into our versatile organs-on-a-chip models and the potential synergy with our supporting assays to accelerate your research, please contact us for more information.

Reference

  1. Sunildutt, N.; et al. Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery. Front Pharmacol. 2023, 14: 1139229. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping part (E) only.
Research Model

Related Sections:

Inquiry Basket
ISO 9001 Certified - Creative Biolabs Quality Management System.
Copyright © Creative Biolabs. All Rights Reserved.
Top