Heart-Liver Two-Organs-on-a-Chip Model Introduction

Creative Biolabs' heart-liver-on-a-chip model accommodates both cardiomyocytes and liver cells, which could successfully maintain both cell lines with more than 90% viability. We develop the model incorporating liver and heart components on a single chip. It has the potential to more realistically capture both the efficacy and the side effects of newly developed drugs, leading to tremendous time and cost savings.

Construction of Our Heart-Liver Two-organs-on-a-chip Model

Fig 1. 3D culture of hiPSC-CM organoids.Fig 1. Exploded view of the liver–heart organoids-on-chip system.1

Features of Our Heart-Liver Two-organs-on-a-chip Model

  • Toxicity evaluation of both parent drug and its metabolites.
  • Easy to operate based on gravity-induced flow and realistic shear stress with our pumpless device.
  • Efficiently predicted drug toxicity not only from acute drug exposure but also from chronic drug treatment.
  • Real-time assessment of cardiac organ function.
  • The capability of maintaining viable cells for long periods.

Applications of Heart-Liver Two-organs-on-a-chip Model

  • Evaluation of cells' functionality in terms of urea production.
  • Prediction of off-target cardiac toxicity upon liver metabolism of drugs.
  • Characterization of fluid dynamics of the model.

Why Choose Us?

Creative Biolabs provides you with a heart-liver two-organs-on-a-chip model that determines appropriate organ sizes and media flow rate, which results in a physiologically realistic system that does not distort the nature of the interactions between organs. Our high-quality model can be implemented as a starting point to move toward a more complex human-on-a-chip device. Visit our website for more organ-on-a-chip models.

Related Services

Our organ-on-a-chip model is well at the commercialization developmental stage, which can fulfil the dual purposes of multiplexing and biological complexity simultaneously. As an in vitro system, our organ-on-a-chip model also can comprehensively capture the entire physiology of an organ or body and discern between the necessary and desirable features at different stages of its translational process. Contact us for an ideal organ-on-a-chip model.

Reference

  1. Farrari, E.; et al. Liver–Heart on chip models for drug safety. APL Bioeng. 2021, 5(3): 031505. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping part(C-i).
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