Overview
Lung-On-A-Chip is a novel air liquid interface model mimicking lung architecture. The microfluidic device is functionalized with epithelial cells surrounded by vasculature comprised of endothelial cells. The structure maintains an air-liquid interface across the airway cells. As a result, airway tubules form and transport mucus and are maintained by the surrounding epithelium. Cell morphology, airway structure, cell-cell interactions, and functions of the airway (e.g. mucus transport, ciliary beating, therapeutic-induced improvements) can be visualized and quantified in real-time in both normal and diseased conditions.
Components
Starter Kit:
10 chips -IMN2 linear (3um slits)
Accessories including tubing, clamps, needles, and syringes
Pneumatic priming device (required for priming tubing to remove air)
Assay Kit:
10 chips - IMN2 linear (3um slits)
Accessories including tubing, clamps, needles, and syringes