Neurotoxicity Evaluation by Brain Organoid

Creative Biolabs offers neurotoxicity evaluation services based on the brain organoid model (BOM), utilizing this advanced technology to assess the impact of compounds on the nervous system.

A New Tool for Neurotoxicity Evaluation: BOM

BOM is a 3D structure that resembles the human brain, generated by differentiating induced pluripotent stem cells (iPSCs) or other stem cells in culture media that mimic the environment of brain development. These organoids can recapitulate the developmental and functional characteristics of the human brain in vitro.

Construction Process

Fig 1. Different types of human brain organoids derived from iPSCs.¹

Tissue Structure

BOM is composed of various types of brain cells, including neurons, glial cells, and neural progenitor cells. These cells self-organize into different regions, such as the cortex, hippocampus, thalamus, and more, following patterns similar to the early embryonic development of the brain. The tissue structure of BOM closely resembles that of the human brain during its early developmental stages.

Functional Characteristics

BOM exhibits physiological functions similar to the human brain, such as forming synaptic connections, generating electrical activity, and transmitting signals.

Advantages of Neurotoxicity Evaluation Application

• Human Relevance

BOM is derived from human pluripotent stem cells, making their tissue structure and functional characteristics more similar to the human brain.

• 3D Structure

Compared to traditional 2D cell cultures, the 3D structure of BOM better represents the realistic physiological environment.

• Disease Modeling

Through gene-editing techniques, various neurological diseases, such as Parkinson's disease and Alzheimer's disease, can be simulated in BOM.

• High-Throughput Screening

Combined with automation and high-throughput technologies, BOM allows large-scale screening of drugs and compounds.

BOM presents a fascinating research tool, providing a model that closely mimics the human brain. Utilizing BOM for neurotoxicity evaluation enables a more reflective assessment of the human nervous system's response to drugs and compounds, offering higher predictive value.

Neurotoxicity Evaluation Services Based on BOM at Creative Biolabs

Creative Biolabs offers comprehensive neurotoxicity evaluation services based on the BOM, which includes the following assessments.

Gene Expression Profiling

Measurement of any abnormal changes in cellular signaling pathways.

Electrophysiological Measurement

Evaluation of cell excitability and functional status.

Single-Cell Sequencing

Understanding cell diversity and potential changes during toxic events.

Cellular Morphological Imaging

Assessment of cell structure and changes.

Calcium Imaging

Detection of level changes in calcium ions related to signal transmission.

Cell Viability Assay

Evaluation of cell vitality and survival status.

Various Behavioral Tests in Mice

Assessment of compound effects on mouse behavior and cognitive function.

The BOM is a revolutionary research tool that can simulate human brain development and function, providing a more reliable and efficient approach for neurotoxicity evaluation. Additionally, Creative Biolabs offers other experimental models that closely resemble human physiological conditions, including:

We have accumulated extensive experience and expertise in this field, providing high-quality services to our clients. If you are seeking top-notch neurotoxicity evaluation services, consider contacting us. Our expert team will tailor a customized solution to meet your research needs, providing full support and explanations to ensure accurate and reliable research results.

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