Pulmonary Fibrosis-on-a-Chip Model Introduction

Idiopathic pulmonary fibrosis (IPF) is a chronic pathological disorder. Here, Creative Biolabs presents you with a novel pulmonary fibrosis-on-a-chip model that is created to model the fibrotic transition of the lung interstitial tissue and the effect of anti-fibrosis drugs on such transitions.

Formation of Our Pulmonary Fibrosis-on-a-chip Model

The pulmonary fibrosis-on-a-chip model consists of arrays of membranous 3D microtissue. During the formation, microtissues undergo morphological and structural changes that are guided by poly (dimethyl siloxane) (PDMS) micropillar-defined mechanical boundary conditions. These membranous lung microtissues recapitulate key biomechanical properties of both healthy and fibrotic lung alveolar tissues.

Fig 1. Design of a platform aimed to mimic lung epithelial injury subsequent to exposure to bleomycin.¹

Why Choose Us

Our pulmonary fibrosis-on-a-chip model offers a range of valuable benefits. It accelerates the analysis of anti-fibrotic therapies, enabling faster assessment of their efficacy. Additionally, it aids in uncovering the underlying mechanisms of action for these therapies, contributing to a deeper understanding of lung biology. This model also serves as a personalized medicine tool, allowing for a better understanding and prediction of treatment effects specific to individual patients.

Apart from the pulmonary fibrosis-on-a-chip model, there are also other models that might capture your interest:

Related Services

Enriching our comprehensive array of disease-on-a-chip models, Creative Biolabs extends its offerings to encompass a range of specialized technical services, tailored to meet the diverse research requirements of our worldwide clients. Feel free to contact us to explore the potential of our extensively customizable models and to obtain a detailed quote.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction