Spinal Cord Injury-on-a-Chip Model Introduction

Creative Biolabs' spinal cord injury-on-a-chip model is a valuable tool for investigating neuronal damage at a cellular level. A specified, reproducible mechanical force has been developed to allow understanding of the complex biomedical mechanisms of spinal cord injuries and the therapeutic strategies for this condition.

Formation of Spinal Cord Injury-on-a-chip Model

The stretch model of our labs' neuronal injury utilizes a flexible substrate on which adherent neurons are cultured. Injury to the cell population is then applied through a substrate. The chip model has two mini-well compartments separated by micro-channels.

Fig 1. Schematic of microengineered device used for 3D MN-SC co-culture.¹

Advanced Spinal Cord Injury-on-a-chip Model at Creative Biolabs

• Wide Array of Neuronal, Glia, and Inflammatory Cellular Populations.
• Relevance to Human Pathophysiology
• Reproducibility, Availability, and Cost-effectiveness
• Potential to Generate Various Severities of Injury

Applications of Spinal Cord Injury-on-a-chip Model

• Impede the ability to study the isolated response of a single cell population to the initial mechanical impact.
• Facilitate the capability for high-throughput initial screening of potential therapeutic targets on a single cell type.
• Further improvement and validation in specific parameters and resources of the investigation.
• Provide an insight into the morphological changes occurring post-injury.

Why Choose Us

Our in vitro spinal cord injury-on-a-chip model has been described in the study field, including transection, compression, and acceleration injuries among others. The closely mimicking pathophysiological and functional features of the spinal cord injury-on-a-chip model can serve as an adequate model to develop and evaluate the structural and functional benefits of therapeutic strategies for spinal cord injuries.

Besides the spinal cord injury-on-a-chip model, we provide several alternative models that may be of significance to your studies:

Related Services

In addition to comprehensive range of models, we also offer a selection of intimate preclinical research services based on 3D biology. With rich experience, our experts possess a deep understanding of varied research needs.

We welcome your inquiries whether technology or the model itself and are always happy to provide any assistance to your research. Please contact us at your convenience to learn more about our highly customizable disease-on-a-chip models and related services.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction