Tumor Organoid and Neo-T Cell Co-Culture Model for Immuno-Oncology Drug Discovery and Development

To aid in the development of immuno-oncology drugs, Creative Biolabs provides co-culture models of tumor organs and neo-T cells.

Significant Roles of Neo-T Cells

Individualized immunotherapy.

Neo-T cells can be a key component of customized immunotherapy since they have the selectivity to target particular malignancies since each patient's tumor has a different tumor genome mutation. Precision therapy for specific malignancies can be accomplished by growing and activating a patient's own neo-T cells in vitro before re-injecting them into the patient.

Immunosurveillance.

By identifying and observing the presence and activity of neo-T cells, one may both comprehend the tumor-killing effect and provide the groundwork for the modification of personalized therapy regimens.

Research into immune escape.

Understanding neo-T cell function can help in the development of therapeutic methods that target immunological escape as well as improve awareness of the mechanisms.

Predicting the responsiveness of immunotherapy.

Neo-T cell counts and activity in tumor samples can be examined to predict how well patients would respond to immunotherapy.

Fig. 1 Neo-T cells immunotherapy.^1,3

Applications

Study the killing mechanism of neo-T cells.

Observing the interaction of T cells with tumor cells in tumor organ-like structures will allow us to better understand how neo-T cells recognize and destroy tumor cells.

Assessing the effectiveness of immunotherapy strategies.

The effect of various therapeutic approaches on tumor organoid structures and neo-T cells can be studied by incorporating medications or checkpoint inhibitors into the model.

Individualized medical research.

Individualized tumor organ-like structures can be constructed using tumor samples from patients, and then tested against different immunotherapy strategies to determine the best treatment option.

Fig 1. Schematic diagram of patient-derived 3D organoid–T cell co-culture models and application.^2,3

Service Process

• Construction and maintenance of tumor organ-like structures by using different cell types and matrices.
• Neo-T cell isolation and culture from the patient's tumor or peripheral blood.
• Examining the relationship between tumor cells and the immune system.
• The ability of neo-T cells to eradicate tumor cells can be assessed using cell viability assays, immunohistochemistry, and other methods.

At Creative Biolabs, our team has extensive expertise in modeling tumor-immune interactions. With our combined efforts, our modeling services help scientists accelerate the discovery of more effective and safer drugs. Please contact us to learn more.

Related Sections:

• Tumor Organoid Monoculture Model for Immuno-Oncology Drug Discovery and Development
• Tumor Organoid and Immune Cell Co-culture Model for Immuno-Oncology Drug Discovery and Development