Tumor Organoid for Immuno-Oncology Drug Discovery and Development

Immuno-oncology drugs (IODs) play a crucial role in cancer treatment, providing new therapeutic options for many cancer patients and demonstrating significant clinical efficacy in certain types of tumors. However, due to the complexity and individual variability of the tumor immune microenvironment, the potential for adverse reactions of varying degrees during future treatment remains a challenge in the development of IODs. To address these challenges, Creative Biolabs offers tumor organoid (TO) construction and functional research services to provide customers with more accurate and reliable research results, thereby advancing the progress of immune-based cancer therapy.

What are Immuno-oncology Drugs (IODs)?

IODs are a class of medications used for cancer treatment that work by modulating the body's immune system to control and eliminate tumor cells (TCs). These drugs can enhance the natural immune defense against tumors and reshape the tumor microenvironment to eliminate TCs.

Action Mechanisms of Immuno-oncology Drugs:

• Monoclonal Antibodies
• Immune Checkpoint Inhibitors
• Cytokine Therapy
• CART-cell Therapy
• Tumor Vaccines
• Oncolytic Virus Therapy

Importance of Immuno-oncology Drugs:

• Provide new treatment options
• Improve treatment outcomes
• Development of personalized therapies
• Overcome drug resistance

Advantages of Tumor Organoid (TO) Models for IOD Discovery and Development

Preservation of tumor heterogeneity:

TO preserves the heterogeneity of the original tumor, including heterogeneity of TCs, presence of cellular subpopulations, and complexity of the tumor microenvironment. This allows researchers to better understand the role of different cell types and components in tumor development and treatment response.

Recapitulation of tumor complexity:

TO is a three-dimensional cell model constructed from patient-derived TCs, capable of mimicking the complexity and structural features of the primary tumor. Compared to traditional two-dimensional cell cultures, TO provides a more physiologically relevant cellular interaction and signaling environment that better reflects the biological characteristics of the tumor.

Therapeutic assessment:

TO can be used to evaluate the functionality and efficacy of immunotherapeutic drugs. Researchers can apply IODs to TO and observe and assess their effects on TC killing, activation, and infiltration of immune cells, thereby guiding the optimization and personalized selection of immunotherapy.

Toxicity assessment:

TO can be utilized to evaluate the toxicity and safety of drugs. By observing the impact of drugs on normal cells within TO, the selective action and potential toxic reactions of drugs can be assessed, providing important references for drug development and optimization.

Personalized medicine research:

Since TO is constructed from patient-derived TCs, they provide a platform for personalized medicine research. Researchers can construct TO tailored to specific patient conditions, such as tumor type and genetic variations, to conduct individualized research and develop personalized treatment strategies.

Fig 1. Main steps of PDO generation and main applications of PDOs.¹

TO Model Construction Services at Creative Biolabs

The application of these two TO models can better simulate the biological characteristics and immune environment of tumors, helping researchers gain a comprehensive understanding of tumor responses and drug resistance mechanisms, as well as evaluate the efficacy and safety of IODs. Creative Biolabs provides customized TO model services, offering reliable experimental platforms and data support for researchers in the field of IOD discovery and development. If you are interested in these two TO model services, please contact us directly for detailed information and assistance.

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