Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights5-hydroxytryptamine (5-HT) receptors, also known as serotonin receptors, are a group of G protein-coupled receptor. They are ligand-gated ion channels in the central and peripheral nervous systems and found in almost all animals. They mediate both excitatory and inhibitory neurotransmission. The 5-HT receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand.
The 5-hydroxytryptamine receptors affect various biological and neurological processes such as appetite, anxiety, mood, cognition, learning, memory, nausea, sleep, thermoregulation, and aggression. Moreover, 5-HT receptors are the target of a variety of pharmaceutical and recreational drugs. And 5-HT receptor modulating drugs have now established their therapeutic role in various disease conditions like emesis, anxiety, and migraine, in various other neurological conditions, as well as peripheral disorders.
Fig.1 Signal transduction of 5-HT receptor subtypes. (Ohno, 2015)
Moreover, 5-hydroxytryptamine is related to carcinoid syndrome which secretes a variety of hormones. The syndrome is readily diagnosed by measuring excretion of 5-HIAA (5-hydroxyindole acetic acid), the main metabolite of 5-HT in the urine. 5-HT receptor modulators may also have some potential in the treatment of cardiovascular system diseases, diabetes, and ocular conditions such as glaucoma. More studies in the future will guide therapeutic potential of 5-HT modulating drugs in other conditions.
Here shows part of the 5-HT receptors in human, e.g. 5-HTI (5-HT1A, 5-HT1B, 5-HTID, 5-HTIE, and 5-HT1F), 5-HT2 (5-HT2A, 5-HT2B, and 5-HT2C), 5-HT3, 5-HT4, 5-HT5 (5-HT5A, 5-HT5B), 5-HT6 and 5-HT7.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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