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etaracizumab/etaratuzumab/MEDI-522 (TAB-705)

DESCRIPTION CATALOG # SIZE PRICE
Anti-αVβ3 integrin Therapeutic Antibody (Abegrin) TAB-705 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant humanized (from mouse) antibody expressed in CHO binding to human αVβ3 integrin. Etaracizumab is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer, ovarian cancer and various other types of cancer.
  • Target
  • αVβ3 integrin
  • Type
  • IgG2 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, IHC and most other immunological methods.
  • CAS
  • 892553-42-3
  • Trade name
  • abegrin
  • Molecular Weight
  • 144.3 kDa
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Size
  • 1mg
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

BACKGROUND

  • Introduction
  • αVβ3 is a type of integrin that is a receptor for vitronectin.[1] It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore it is a receptor for phagocytosis on macrophages or dendritic cells.[2]

    Inhibitors like etaracizumab may be used as antiangiogenics.
  • Antigen Description
  • integrin, beta 3.The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
  • Keywords
  • αVβ3

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