yttrium (90Y) tacatuzumab tetraxetan

Cat

TAB-713

Product Overview

Recombinant humanized (from mouse) antibody expressed in CHO binding to human AFP. Yttrium (90Y) tacatuzumab tetraxetan is a humanized monoclonal antibody intended for the treatment of cancer. The antibody itself, tacatuzumab, is conjugated with tetraxetan, a chelator for yttrium-90, a radioisotope which destroys the tumour cells.

Target

AFP

Type

IgG1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, WB and most other immunological methods.

CAS

476413-07-7

Trade name

afp-cide

Molecular Weight

145 kDa

Purity

>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Size

1mg

Storage

Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Introduction

Yttrium (90Y) tacatuzumab tetraxetan is a humanized monoclonal antibody intended for the treatment of cancer.

Antigen Description

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

Function

metal ion binding;

Gene ID

174

Synonyms

AFP; alpha-fetoprotein; HPAFP; FETA; alpha-fetoglobulin; alpha-1-fetoprotein;

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