nesvacumab

Cat

TAB-769

Product Overview

Recombinant human monoclonal antibody expressed in CHO binding to human ANGPT2. Nesvacumab is a monoclonal antibody designed for the treatment of cancer.

Target

ANGPT2

Type

IgG1

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.

CAS

1296818-77-3

Predicted N terminal

EVQLVESG

Molecular Weight

144.9 kDa

Purity

>95.0% as determined by analysis by RP-HPLC.

Size

1mg

Storage

Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Introduction

Nesvacumab is a monoclonal antibody designed for the treatment of cancer.

Antigen Description

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.

Function

metal ion binding; protein binding; receptor binding; receptor tyrosine kinase binding;

Gene ID

285

Synonyms

ANGPT2; angiopoietin 2; angiopoietin-2; Ang2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; ANG2; AGPT2;

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