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Raxibacumab (TAB-224)

DESCRIPTION CATALOG # SIZE PRICE
Anti-B. anthracis anthrax protective antigen (PA) Therapeutic Antibody (ABthrax) TAB-224 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
  • Target
  • Bacillus anthracis
  • Type
  • IgG1 - lambda
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • B. anthracis
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, ICC and most other immunological methods.
  • CAS
  • 565451-13-0
  • Trade name
  • abthrax
  • Specificity
  • Tested positive against native B. anthracis antigen.
  • Molecular Weight
  • 142930
  • Purity
  • >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

BACKGROUND

  • Introduction
  • This is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax.
  • Antigen Description
  • Anthrax toxins are composed of three distinct proteins, a protective antigen (PA), a lethal factor (LF) and an edema factor (EF). None of these proteins are toxic by themselves and several studies indicate that the anthrax toxin has the familiar A-B enzymatic binding structure, with PA acting as the binding domain and EF and/or LF acting as the active fragments.
  • Keywords
  • anthrax PA; Anthrax Protective Antigen; Anthrax toxins translocating protein; Bacillus anthracis Protective Antigen; PA 83; PA; PA83; Pag; PagA; Protective antigen

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