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Recombinant human monoclonal antibody expressed in CHO binding to human CCL11. Bertilimumab is a human monoclonal antibody that binds to eotaxin-1, an important regulator of overall eosinophil function. It was to be used to treat severe allergic disorders.
IgG4 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in ELISA, Neut, IF, IP, FC, FuncS and most other immunological methods.
Approximately 150 kDa
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
Bertilimumab is a human monoclonal antibody that binds to eotaxin-1, an important regulator of overalleosinophil function.
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.