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Recombinant humanized antibody expressed in CHO binding to human MS4A1/CD20. Ocrelizumab is a humanized anti-CD20 monoclonal antibody. It targets mature B lymphocytes and hence is an immunosuppressive drug candidate. It had reached Phase III clinical trials for rheumatoid arthritis and lupus erythematosus, and Phase II for multiple scleros is and hematological cancer.
The details of the immunogen for this antibody are not available.
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
>95%, by SDS-PAGE with silver staining, under reducing conditions.
Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Ocrelizumab is a humanized anti-CD20 monoclonal antibody. It targets mature B lymphocytes and hence is animmunosuppressive drug candidate.
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.