lintuzumab

Cat

TAB-756

Product Overview

Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD33. Lintuzumab is a humanized monoclonal antibody used in the treatment of cancer.

Target

CD33

Type

IgG1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

Sp2/0 mouse myeloma cells

Applications

Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.

CAS

166089-32-3

Trade name

zamyl/smart

Predicted N terminal

QVQLVQSG

Molecular Weight

46.96 kDa

Purity

>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Size

1mg

Storage

Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Introduction

Lintuzumab (SGN-33) is a humanized monoclonal antibody used in the treatment of cancer.

Antigen Description

CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage.It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

Function

receptor activity; sugar binding;

Gene ID

945

Synonyms

CD33; CD33 molecule; CD33 antigen (gp67); myeloid cell surface antigen CD33; FLJ00391; p67; sialic acid binding Ig like lectin 3; SIGLEC 3; SIGLEC3; gp67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC-3;

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