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bivatuzumab (TAB-727)

DESCRIPTION CATALOG # SIZE PRICE
Anti-CD44 Therapeutic Antibody TAB-727 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. Bivatuzumab is a humanized monoclonal antibody against CD44 v6. It has been chemically linked to various radioisotopes for use in radiotherapy for, e.g. inoperable recurrent or metastatic head and neck cancer. It has also been linked to a cytotoxic drug mertansine to form bivatuzumab mertansine.
  • Target
  • CD44
  • Type
  • IgG1
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
  • CAS
  • 214599-60-1
  • Molecular Weight
  • Approximately 150 kDa
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • At -20°C for one year.

BACKGROUND

  • Introduction
  • Bivatuzumab (previously BIWA 4) is a humanized monoclonal antibody against CD44 v6.
  • Antigen Description
  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
  • Function
  • binding; collagen binding; hyaluronic acid binding; hyaluronic acid binding; hyaluronic acid binding; hyalurononglucosaminidase activity; protein binding; receptor activity; contributes_to transmembrane signaling receptor activity;
  • Synonyms
  • CD44; CD44 molecule (Indian blood group); CD44 antigen (homing function and Indian blood group system) , MDU2, MDU3, MIC4; CD44 antigen; CD44R; chondroitin sulfate proteoglycan 8; CSPG8; HCELL; hematopoietic cell E and L selectin ligand; IN; MC56; Pgp1; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system; LHR; MDU2; MDU3; MIC4; CDW44; HUTCH-I; ECMR-III; MGC10468;

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