lampalizumab

Cat

TAB-754

Product Overview

Recombinant humanized (from mouse) antibody Fab fragment expressed in CHO binding to human CFD. Lampalizumab is a humanized monoclonal antibody designed for the treatment of geographic atrophy secondary to age-related macular degeneration.

Target

CFD

Type

Fab - G1 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.

CAS

1278466-20-8

Predicted N terminal

EVQLVQSG

Molecular Weight

46.96 kDa

Purity

>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Size

1mg

Storage

Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

Introduction

Lampalizumab is a humanized monoclonal antibody designed for the treatment of geographic atrophy secondary to age-related macular degeneration.

Antigen Description

The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.

Function

peptidase activity; serine-type endopeptidase activity; serine-type peptidase activity;

Gene ID

1675

Synonyms

CFD; complement factor D (adipsin); D component of complement (adipsin) , DF, PFD, properdin factor D; complement factor D; ADN; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin); DF; PFD; ADIPSIN;

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