glembatumumab

Cat

TAB-751

Product Overview

Recombinant human monoclonal antibody expressed in CHO binding to human GPNMB. Glembatumumab vedotin is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB).

Target

GPNMB

Type

IgG2 - kappa

Immunogen

The details of the immunogen for this antibody are not available.

Species Reactivity

Human

Expression Host

CHO

Applications

Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, WB and most other immunological methods.

CAS

1020264-78-1

Predicted N terminal

QVQLQESG

Molecular Weight

Approximately 150 kDa

Purity

>95.0% as determined by analysis by RP-HPLC.

Size

1mg

Storage

Store at -20°C. Avoid multiple freeze/thaw cycles.

Introduction

Glembatumumab vedotin is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB).

Antigen Description

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.

Function

heparin binding; integrin binding;

Gene ID

10457

Synonyms

GPNMB; glycoprotein (transmembrane) nmb; transmembrane glycoprotein NMB; glycoprotein NMB; glycoprotein nmb like protein; HGFIN; NMB; osteoactivin; transmembrane glycoprotein; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN;

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