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Recombinant monoclonal antibody to Abeta. Gantenerumab is a monoclonal antibody for the treatment of Alzheimer's disease. A phase I clinical trial has been conducted in 2006/07. Gantenerumab is currently being evaluated in a prodromal Alzheimer's Disease population in the Scarlet Road study, a global phase II study of approximately 360 subjects in 100 centers in 15 countries.
IgG1 - kappa
The details of the immunogen for this antibody are not available.
Suitable for use in WB, IF, IP, Neut, FuncS, ELISA, FC and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G1, anti-(human beta-amyloid peptides A beta42 and A beta40) human monoclonal antibody; gamma1 heavy chain (Homo sapiens VH-IGHG1) (229-215")-disulfide with kappa light chain (Homo sapiens V-KAPPA-IGKC); (235-235":238-238")-bisdisulfide dimer
Predicted N terminal
H chain: QVELVES; L chain: DIVLTQS
>95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; trans