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Solanezumab (TAB-228)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Abeta Therapeutic Antibody TAB-228 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Abeta. It binds to the amyloid-β peptides that make up the protein plaques seen in the brains of people with the disease.
  • Target
  • Abeta
  • Type
  • IgG1 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, FuncS, IF, Neut, ELISA, FC, IP and most other immunological methods.
  • CAS
  • 955085-14-0
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1-kappa, anti-[Homo sapiens amyloid-beta (Abeta) peptide soluble monomer], humanized monoclonal antibody; gamma1 heavy chain [humanized VH (Homo sapiens IGHV3-23*04 (87.60%) -(IGHD)-IGHJ4*01) [8.8.5] (1-112) -Homo sapiens IGHG1*01, CH3 K130>del (113-441)], (215-219")-disulfide with kappa light chain (1"-219") [humanized V-KAPPA (Homo sapiens IGKV2-30*01 (90.00%) -IGKJ1*01) [11.3.9] (1"-112") -Homo sapiens IGKC*01 (113"-219")]; (221-221":224-224")-bisdisulfide dimer
  • Predicted N terminal
  • H chain: EVQLVES; L chain: DVVMTQS
  • Molecular Weight
  • 144082
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Size
  • 1mg
  • Storage
  • Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.

BACKGROUND

  • Antigen Description
  • Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
  • Function
  • DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; trans
  • Synonyms
  • APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;

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