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Ponezumab (TAB-227)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human Abeta Therapeutic Antibody TAB-227 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to Abeta. Ponezumab is a humanized monoclonal antibody designed for the treatment of Alzheimer's disease.
  • Target
  • Abeta
  • Type
  • IgG2 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, ELISA, IP, FC, FuncS, Neut, IF and most other immunological methods.
  • CAS
  • 1178862-65-1
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G2, anti-(human beta-amyloid) (human-mouse monoclonal PF-04360365 clone 9TL heavy chain), disulfide with human-mouse monoclonal PF-04360365 clone 9TL light chain, dimer
  • Predicted N terminal
  • H chain: QVQLVQS; L chain: DVVMTQS
  • Molecular Weight
  • 148270
  • Purity
  • >95.0% as determined by analysis by RP-HPLC.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Defects in APP are the cause of Alzheimer disease type 1 (AD1) [MIM:104300]. AD1 is a familial early-onset form of Alzheimer disease.
  • Function
  • DNA binding; PTB domain binding; acetylcholine receptor binding; heparin binding; identical protein binding; peptidase activator activity; peptidase inhibitor activity; protein binding; receptor binding; serine-type endopeptidase inhibitor activity; trans
  • Synonyms
  • APP; amyloid beta (A4) precursor protein; AD1, Alzheimer disease; amyloid beta A4 protein; peptidase nexin II; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma;

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