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Recombinant monoclonal antibody to Human BLyS. Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). B cells are responsible for part of the normal immune response, and also for the over-aggressive immune response in autoimmune diseases like systemic lupus erythematosus (SLE).
IgG1 - lambda
The details of the immunogen for this antibody are not available.
Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, ICC and most other immunological methods.
Tested positive against native human antigen
ImmunoglobulinG1, anti-(human cytokine BAFF) (human monoclonal LymphoStat-B heavy chain),disulfide with human monoclonal LymphoStat-B l-chain, dimer
Purity >95% by SDS-PAGE.
At -20°C for one year.
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.