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Abagovomab (TAB-114)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CA-125 Therapeutic Antibody TAB-114 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to CA-125. Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.
  • Target
  • CA 125
  • Type
  • IgG1 - kappa
  • Immunogen
  • CA-125 purified from human ovarian carcinoma.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
  • CAS
  • 792921-10-9
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1,anti-(mouse OC 125) (mouse monoclonal ACA-125 clone 3D5 g-chain), disulfide with mousemonoclonal ACA-125 clone 3D5 k-chain, dimer
  • Purity
  • >95.0% as determined by analysis by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Antigen Description
  • CA 125 (cancer antigen 125) is a tumour marker or biomarker that may be elevated in the blood of some people with specific types of cancers. CA 125 is a mucinous glycoprotein and the product of the MUC16 gene. It is best known as a marker for ovarian cancer, but it may also be elevated in other malignant cancers.
  • Function
  • protein binding;
  • Synonyms
  • MUC16; mucin 16, cell surface associated; mucin-16; CA125; FLJ14303; CA-125; MUC-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125;

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