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Recombinant monoclonal antibody to CA-125. Abagovomab is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen (CA-125) highly expressed in the epithelial ovarian cancer. Abagovomab does not bind directly to CA-125, but it works as a "surrogate" antigen, enabling the immune system to identify and attack tumour cells displaying the CA-125 protein. Through this, it is hoped that the body's immune system may be able to combat any remaining individual tumour cells and thus prevent recurrence of the disease.
IgG1 - kappa
CA-125 purified from human ovarian carcinoma.
Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
CA 125 (cancer antigen 125) is a tumour marker or biomarker that may be elevated in the blood of some people with specific types of cancers. CA 125 is a mucinous glycoprotein and the product of the MUC16 gene. It is best known as a marker for ovarian cancer, but it may also be elevated in other malignant cancers.