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denintuzumab mafodotin (TAB-H17)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD19 Therapeutic Antibody TAB-H17 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Humanized antibody to Human CD19
  • Type
  • IgG1 - kappa
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in Neut, ELISA, IF, IP, FuncS, FC, WB and most other immunological methods.
  • CAS
  • 1399672-02-6
  • Specificity
  • CD19 (B lymphocyte surface antigen B4, Leu-12) [Homo sapiens]
  • Protein Construction
  • SGN-19A is an ADC comprised of a humanized anti-CD19 mAb and the potent cytotoxic drug-linker maleimidocaproyl monomethyl auristatin F(mcMMAF).gamma1 heavy chain (1-450) [humanized VH (Homo sapiens IGHV4-31*02 (84.80%) – (IGHD) – IGHJ4*01) [10.7.12] (1-120) – Homo sapiensIGHG1*01 (CH1 (121-218), hinge (219-233), CH2 (234-343), CH3 (344-448), CHS (449-450)) (121-450)], (223-213') – disulfide withkappa light chain (1'-213') [humanized V-KAPPA (Homo sapiens IGKV3-11*01 (85.30%) -IGKJ2*02) [5.3.9] (1'-106') – Homo sapiens IGKC*01(107'-213')]; dimer (229-229":232-232") – bisdisulfide; conjugated, on an average of 4 cysteinyl, to monomethylauristatin F (MMAF), via anoncleavable maleimidocaproyl (mc) linker
  • Purity
  • >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.

BACKGROUND

  • Antigen Description
  • B-lymphocyte antigen CD19 also known as CD19 (Cluster of Differentiation 19), is a protein that in humans is encoded by the CD19 gene. It is found on the surface of B-cells, a type of white blood cell.
  • Function
  • receptor signaling protein activity;
  • Synonyms
  • CD19; CD19 molecule; CD19 antigen; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4; B4; CVID3; MGC12802;

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