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Siplizumab (TAB-104)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD2 Therapeutic Antibody TAB-104 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
  • Target
  • CD2
  • Type
  • IgG1 - kappa
  • Immunogen
  • Human CD2 recombinant protein
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
  • CAS
  • 288392-69-8
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G1,anti-(human CD2 (antigen)) (human-rat monoclonal MEDI-507 g1-chain), disulfide withhuman-rat monoclonal MEDI-507 light chain, dimer
  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Size
  • 1mg
  • Storage
  • At -20°C for one year.

BACKGROUND

  • Antigen Description
  • CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
  • Function
  • eukaryotic cell surface binding; protein binding; protein homodimerization activity; receptor activity; receptor activity;
  • Synonyms
  • CD2; CD2 molecule; CD2 antigen (p50), sheep red blood cell receptor , SRBC; T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor; T11; SRBC; LFA-2; FLJ46032;

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