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Recombinant monoclonal antibody to CD2. Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.
IgG1 - kappa
Human CD2 recombinant protein
Suitable for use in ELISA, IP, FC, FuncS, Neut, IF, ICC and most other immunological methods.
>95%, by SDS-PAGE with silver staining, under reducing conditions.
At -20°C for one year.
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
eukaryotic cell surface binding; protein binding; protein homodimerization activity; receptor activity; receptor activity;