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Afutuzumab (TAB-133)

DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD20 Therapeutic Antibody TAB-133 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody to CD20. Afutuzumab is a monoclonal antibody for the treatment of lymphoma. It acts as an immunomodulator.
  • Target
  • CD20
  • Type
  • IgG3 - kappa
  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in IP, IF, FuncS, FC, Neut, ELISA, ICC and most other immunological methods.
  • CAS
  • 949142-50-1
  • Specificity
  • Tested positive against native human antigen.
  • Protein Construction
  • immunoglobulin G1, anti-[Homo sapiens CD20], humanized monoclonal antibody, GA101; gamma1 heavy chain (1-448) [humanized VH (Homo sapiens FR/Mus musculus CDR, Homo sapiens IGHJ4*01) [8.8.12] (1-119) -Homo sapiens IGHG1*01 (120-448)], (222-219")-disulfide with kappa light chain (1"-219") [humanized V-KAPPA (Homo sapiens FR/Mus musculus CDR, Homo sapiens IGKJ4*01) [11.3.9] (1"-112") -Homo sapiens IGKC*01 (113"-219")]; (228-228"":231-231"")-bisdisulfide dimer
  • Predicted N terminal
  • H chain: QVQLVQS; L chain: DIVMTQS
  • Molecular Weight
  • 146062
  • Purity
  • >95%, by SDS-PAGE with silver staining, under reducing conditions.
  • Size
  • 1mg
  • Storage
  • 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.

BACKGROUND

  • Antigen Description
  • CD20 is B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells.
  • Function
  • epidermal growth factor receptor binding;
  • Synonyms
  • MS4A1; membrane-spanning 4-domains, subfamily A, member 1; CD20; B-lymphocyte antigen CD20; B1; Bp35; MS4A2; CD20 antigen; CD20 receptor; leukocyte surface antigen Leu-16; B-lymphocyte cell-surface antigen B1; S7; CVID5; LEU-16; MGC3969;

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