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Recombinant monoclonal antibody fragment Fab to CD22. Bectumomab (marketed under the trade name LymphoScan) is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m. It is used to detect non-Hodgkin's lymphoma.
Fab' - G2a - kappa
A combination of recombinant human CD22 extracellular 25 domain and CHO ceIls engineered to express full-length human CD22 on the ceIl surface
Suitable for use in FC, IP, ELISA, Neut, FuncS, IF, WB and most other immunological methods.
Tested positive against native human antigen.
Immunoglobulin G2a,anti-(human CD22 (antigen))Fab fragment (mouse monoclonal IMMU-LL2 g2a-chain), disulfide with mousemonoclonal IMMU-LL2 light chain
Predicted N terminal
H chain: EVQLVQS; L chain: EIVLTQS
Purity >95% by SDS-PAGE.
Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.